Bone Turnover Markers
The monitoring of serum or urinary markers
of bone turnover, in conjunction with BMD measurement,
is an evolving method of clinical assessment.
A meta-analysis of randomized controlled-trials
of antiresorptive treatments in postmenopausal
women with osteoporosis demonstrated that large
changes in biochemical markers of bone turnover
(70% reduction in bone resorption markers and
50% reduction in bone formation markers) were
associated with over 40% reduction in nonvertebral
fractures.18 Bone turnover markers may help
improve patient compliance with osteoporosis
therapies and in assessing therapeutic response.
However, their clinical role in the management
of osteoporosis is not established.10
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